Facile prix doxycycline belgique original

Abstract

Background

The use of antibiotics during pregnancy and neonatal period is associated with higher risk of adverse reactions. The incidence of neonatal reactions is increasing with the recent increase of the use of antibiotics. However, the clinical tolerance of the use of antibiotics during pregnancy is still poor and most cases are associated with adverse reactions. This study aims to evaluate the efficacy of doxycycline antibiotics in pregnancy and neonatal period in a French university-based population. Methods

The medical data of the patients who were enrolled in this study were collected from the medical databases. The medical records of the patients were compared by the International Normalized Ratio, and the number of pregnancies was compared with that of the general population. The data were obtained from the databases and the medical files were compared by the Chi-square test. The statistical analyses were performed using the Statistical Package for Social Sciences (SPS, version 19.0; SPSS, Chicago, IL, USA). The study was conducted in a tertiary-level university hospital with a charge of French language medical center. The primary outcome was the occurrence of neonatal reactions (NRT). The study was approved by the institutional review board of the university hospital. The patients were divided into 2 groups: group A: patients who received antibiotics at the university hospital, group B: patients who did not receive antibiotics at the university hospital. The data were analyzed by 2 way analysis of variance (ANOVA). Pertaining to the primary outcome, we used the Chi-square test to compare the difference between the two groups. A value of P≤0.05 was considered significant. Statistical analysis was performed using SPS, version 19.0. The statistical analyses were performed using the Statistical Package for Social Sciences (SPS, version 19.0; SPSS, Chicago, IL, USA).

Results

Results of the study included 1 839 neonates. The mean age of the patients was 14.9 years (SD 6.1). Of the patients, 57 (23.6%) had no significant difference between the two groups. The average birth weight of the patients was 9.7 kg (SD 1.7). The incidence of the NRT was 17.3%. The average time of onset of symptoms was 7.9 days (SD 2.1). The mean number of NRT was 7.1 (SD 2.8). The mean number of antibiotics was 13.2 (SD 5.5) in the 1 839 patients and 14.4 (SD 3.1) in the 1 839 patients.

Conclusion

The use of doxycycline in pregnancy and neonatal period is associated with higher risk of NRT. The clinical tolerance of doxycycline antibiotics during pregnancy and neonatal period is poor. This study demonstrated that the use of doxycycline during pregnancy and neonatal period is associated with higher risk of NRT. This study suggests that doxycycline antibiotics should be considered in pregnancy and neonatal period for the treatment of the risk of NRT.

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